B cell defects observed in Nod2 knockout mice are a consequence of a Dock2 mutation frequently found in inbred strains
S.-Y. Wong, M. Coffre, D. Ramanan, L. E. Gomez, L. Peters, E. Schadt, S. Koralov, K. Cadwell
The paper identifies a Dock2 mutation in Nod2-/- mice that causes B cell defects, independent of Nod2 deletion, and shows the mutation is common in inbred strains.
bioRxiv · Jan 4, 2018Immunology