Bispecific antibody shuttles targeting CD98hc mediate efficient and long-lived brain delivery of IgGs
G. Pornnoppadol, L. G. Bond, M. J. Lucas, J. M. Zupancic, Y.-H. Kuo, B. Zhang, C. F. Greineder, P. M. Tessier
This paper develops bispecific antibody shuttles targeting CD98hc for efficient and long-lived brain delivery of IgGs, showing improved retention and specificity compared to TfR-1 shuttles.
bioRxiv · Apr 29, 2023Bioengineering