P. M. Tessier

In vivo Auto-tuning of Antibody-Drug Conjugate Delivery for Effective Immunotherapy using High-Avidity, Low-Affinity Antibodies

This study develops HALA antibodies that adjust ADC delivery based on tumor HER2 expression, improving efficacy across varying expression levels in preclinical models.

Facile generation of biepitopic antibodies with intrinsic agonism for activating receptors in the tumor necrosis factor superfamily

This paper describes a method to generate biepitopic antibodies that activate TNF receptors by combining single-chain antibodies with IgG light chains, enhancing agonist activity without animal immunization.

Flow cytometric isolation of drug-like conformational antibodies specific for amyloid fibrils

This paper describes a FACS method using quantum dots to isolate high-quality conformational antibodies against insoluble antigens like amyloid fibrils.

Quantitative flow cytometric selection of tau conformational nanobodies specific for pathological aggregates

This study selects conformational nanobodies specific for aggregated tau using flow cytometry, showing their utility in detecting tau aggregates in mouse and human samples.

Bispecific antibody shuttles targeting CD98hc mediate efficient and long-lived brain delivery of IgGs

This paper develops bispecific antibody shuttles targeting CD98hc for efficient and long-lived brain delivery of IgGs, showing improved retention and specificity compared to TfR-1 shuttles.

Reliable energy-based antibody humanization and stabilization

The paper introduces CUMAb, a computational method for humanizing antibodies that improves stability and binding by systematically grafting CDRs onto human frameworks and ranking designs using Rosetta simulations.