Combining LSD1 and JAK-STAT inhibition targets Down syndrome-associated myeloid leukemia at its core
J. Grimm, R. Bhayadia, L. Gack, D. Heckl, J.-H. Klusmann
This study shows that combining LSD1 and JAK-STAT inhibition effectively targets Down syndrome-associated myeloid leukemia by synergistically repressing cell division and enhancing immunogenicity.
bioRxiv · Jan 14, 2022Cancer Biology