J. Grimm

Nanoscale imaging reveals the mechanisms of ER-to-Golgi transport via a dynamic tubular-vesicular network

This study uses live-cell imaging to show ER-to-Golgi transport occurs via a dynamic ARF4 tubular-vesicular network connected to the ER and Golgi.

Vascularized tumor on a microfluidic chip to study mechanisms promoting tumor neovascularization and vascular targeted therapies

This study develops a microfluidic chip model of vascularized tumors to evaluate angiogenesis and vascular-targeted therapies, showing bevacizumab disrupts tumor-vessel interactions and enables rapid drug assessment.

Radiances of Cerenkov-Emitting Isotopes on the IVIS

The paper presents the largest experimental dataset of Cerenkov-emitting isotopes measured using IVIS, providing normalized radiance values for 21 isotopes across various emissions.

Preclinical shortwave infrared tumor screening and resection via pHLIP ICG under ambient lighting conditions

This study demonstrates that SWIR imaging with pHLIP ICG enables sensitive tumor detection and resection under ambient lighting conditions in a preclinical breast cancer model.

PSMA-bearing extracellular vesicles secreted from prostate cancer convert the microenvironment to a tumor-supporting, pro-angiogenic state.

The paper shows that PSMA-bearing extracellular vesicles from prostate cancer cells promote a pro-angiogenic tumor microenvironment by increasing VEGF-A, angiogenin, and 4EBP-1 phosphorylation.

Combining LSD1 and JAK-STAT inhibition targets Down syndrome-associated myeloid leukemia at its core

This study shows that combining LSD1 and JAK-STAT inhibition effectively targets Down syndrome-associated myeloid leukemia by synergistically repressing cell division and enhancing immunogenicity.

Optoacoustic imaging of GLP-1 Receptor with a near-infrared exendin-4 analog

This paper develops and validates a near-infrared optoacoustic contrast agent for imaging GLP-1R-expressing cells in vivo.

Bioorthogonal labeling with tetrazine-dyes forsuper-resolution microscopy

This study explores the use of tetrazine-dyes in super-resolution microscopy via Diels-Alder reactions with TCO-modified ncAAs, showing enhanced fluorescence and specific labeling capabilities.

Visualizing Long-Term Single-Molecule Dynamics in vivo by Stochastic Protein Labeling

This paper introduces a genetic strategy for sparse protein labeling in live cells, enabling long-term single-molecule tracking and revealing new insights into molecular dynamics in vivo.

Cohesin Can Remain Associated With Chromosomes During DNA Replication

The paper investigates whether cohesin complexes from G1 phase remain associated with chromatin during DNA replication, finding that they persist in S phase when cohesin turnover is inhibited.