Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams-Beuren syndrome
A. Navarro-Romero, L. Galera-Lopez, P. Ortiz-Romero, A. Llorente-Ovejero, L. de los Reyes-Ramirez, A. Mas-Stachurska, M. Reixachs-Sole, A. Pastor, R. de la Torre, R. Maldonado, B. Benito, E. Eyras, R. Rodriguez-Puertas, V. Campuzano, A. Ozaita
This study shows that JZL184 treatment improves social, cognitive, and cardiac phenotypes in a mouse model of Williams-Beuren syndrome by modulating the endocannabinoid system.
bioRxiv · Aug 16, 2021 · PreprintAnimal Behavior & Cognition