R. Maldonado

The long non-coding RNA MALAT1 modulates NR4A1 expression through a downstream regulatory element in specific cancer-cell-types

This study identifies MALAT1's role in regulating NR4A1 expression via a downstream regulatory element in specific cancer cell types using RNA- and ATAC-seq.

Prefrontal accumbens neural dynamics abnormalities in mice vulnerable to develop food addiction

This study identifies disrupted mPFC-NAc neural dynamics in mice with food addiction, showing that rimonabant restores these abnormalities.

Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams-Beuren syndrome

This study shows that JZL184 treatment improves social, cognitive, and cardiac phenotypes in a mouse model of Williams-Beuren syndrome by modulating the endocannabinoid system.

Reduced cue-induced reinstatement of cocaine seeking behavior in Plcb1+/- mice

This study shows that Plcb1+/- mice exhibit reduced cue-induced reinstatement of cocaine seeking, suggesting PLCB1 as a potential therapeutic target for cocaine addiction.

Protective role of neuronal and lymphoid cannabinoid CB2 receptors in neuropathic pain

This study shows that neuronal and lymphoid CB2 receptors work together to protect against neuropathic pain by reducing spontaneous and evoked pain behaviors in mice.

Disease-modifying effects of natural Δ9-tetrahydrocannabinol in endometriosis-associated pain

This study evaluates the effects of chronic THC exposure in a mouse model of endometriosis, finding reduced pelvic hypersensitivity, restored cognitive function, and inhibited cyst development.