Inhibition of Retinoic Acid Signaling in Proximal Tubular Epithelial cells Protects against Acute Kidney Injury by Enhancing Kim-1-dependent Efferocytosis
M. Yang, L. N. Lopez, M. Brewer, R. D. Delgado, A. A. Menshikh, K. A. Clouthier, Y. Zhu, T. Vanichapol, H. Yang, R. Harris, L. Gewin, C. R. Brooks, A. Davidson, M. de Caestecker
The paper shows that inhibiting RAR signaling in PTECs during AKI increases Kim-1 expression, which enhances efferocytosis and protects against injury.
bioRxiv · Jun 15, 2023 · PreprintPathology