R. Harris

Elevation-dependent patterns of snow-gum dieback are moderated by trait differences between montane and subalpine forests.

The paper examines elevation-dependent patterns of snow-gum dieback and finds trait differences between montane and subalpine subspecies influence borer-damage severity.

Introgression underlies phylogenetic uncertainty but not parallel plumage evolution in a recent songbird radiation

The paper investigates phylogenetic uncertainty and parallel plumage evolution in wagtails using whole genome data, finding introgression causes gene tree discordance but not parallel plumage evolution.

Mesoscale DNA Features Impact APOBEC3A and APOBEC3B Deaminase Activity and Shape Tumor Mutational Landscapes

This study identifies how mesoscale DNA features influence APOBEC3A and APOBEC3B deaminase activity and their impact on tumor mutational landscapes.

Inhibition of Retinoic Acid Signaling in Proximal Tubular Epithelial cells Protects against Acute Kidney Injury by Enhancing Kim-1-dependent Efferocytosis

The paper shows that inhibiting RAR signaling in PTECs during AKI increases Kim-1 expression, which enhances efferocytosis and protects against injury.

Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors

The paper identifies SARS-CoV-2 variants resistant to protease inhibitors nirmatrelvir and ensitrelvir, showing pre-existing resistance and potential for spread.

Rapid resistance profiling of SARS-CoV-2 protease inhibitors

The paper compares resistance profiles of nirmatrelvir, ensitrelvir, and FB2001 against SARS-CoV-2 Mpro variants using a cell-based assay, revealing distinct resistance mechanisms.

Human APOBEC3B promotes tumor heterogeneity in vivo including signature mutations and metastases

This study shows that human APOBEC3B causes tumor heterogeneity and metastases in mice, with increased C-to-T mutations and structural variations.

Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductases

The paper investigates how gamma-herpesvirus ribonucleotide reductases antagonize APOBEC3B, showing conservation across human and Old World monkey-infecting viruses but not New World monkey-infecting viruses.

Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells.

This study identifies Fbxo7's role in promoting Cdk6 activity to inhibit PFKP and glycolysis in T cells, revealing its impact on metabolism and viability.

Nanoengineered DNA origami with repurposed TOP1 inhibitors targeting myeloid cells for the mitigation of neuroinflammation

The paper identifies TOP1 inhibitors as therapeutic agents for neuroinflammation and develops a DNA origami nanosystem for targeted delivery to myeloid cells.

CryoEM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition

This study reveals how EBV's BORF2 protein inhibits APOBEC3B by blocking its access to DNA, providing insights for drug development.

R-loop homeostasis and cancer mutagenesis promoted by the DNA cytosine deaminase APOBEC3B

This study shows APOBEC3B regulates R-loop homeostasis and contributes to mutagenesis in cancer by binding R-loops and altering their landscape.

Comprehensive analysis of clustered mutations in cancer reveals recurrent APOBEC3 mutagenesis of ecDNA

The paper analyzes clustered mutations in 2,583 cancer genomes, identifying APOBEC3-driven mutagenesis on ecDNA as a significant contributor to cancer evolution.

Wnt/β-catenin regulates alloreactive T cells for the treatment of hematological malignancies

This study shows that β-catenin regulates donor T cells in allo-HSCT, reducing GVHD while preserving GVL effects through altered cytokine production and cytotoxicity.

TCF-1 in CD4 T cells regulates GVHD severity and persistence

This study shows that loss of TCF-1 in mature CD4 T cells reduces GVHD severity and persistence by impairing T cell function and increasing exhaustion.

TCF-7 is dispensable for the anti-tumor response but required for the persistent function of mature CD8 T cells

This study shows TCF-7 is not needed for anti-tumor response but is required for long-term function of mature CD8 T cells.

Loss of TCF-1 regulates the production of noncanonical Tregs in a prion-like manner

The paper shows that loss of TCF-1 expands noncanonical Tregs and that TCF-1-deficient T cells promote their production from wild-type cells.

Coevolution between primates and venomous snakes revealed by α-neurotoxin susceptibility

This study identifies reduced susceptibility to snake α-neurotoxins in catarrhine primates, supporting coevolutionary arms-race between primates and venomous snakes.

An immunogenic model of KRAS-mutant lung cancer for study of targeted therapy and immunotherapy combinations

This paper develops an immunogenic mouse model of KRAS-mutant lung cancer that responds to immunotherapy and reveals immune responses target endogenous retroviral antigens rather than neoantigens.

Gain-of-function assay for SARS-CoV-2 Mpro inhibition in living cells

The paper develops a gain-of-function assay to measure SARS-CoV-2 Mpro inhibition in living cells, using eGFP fluorescence to quantify inhibitor potency and enable high-throughput drug testing.

Isolating the role of corticosterone in the hypothalamic-pituitary-gonadal genomic stress response

This study examines the genomic effects of corticosterone on the HPG axis in rock doves under stress, identifying sex-specific gene expression changes and shared genes in the pituitary.

Feasibility of Integrating Canine Olfaction with Chemical and Microbial Profiling of Urine to Detect Lethal Prostate Cancer

This study tests the feasibility of using canine olfaction, VOC analysis, and microbial profiling in urine to detect lethal prostate cancer, showing 71% sensitivity and 70-76% specificity.

Identification of SARS-CoV-2 induced pathways reveal drug repurposing strategies

The paper identifies 200 approved drugs that target SARS-CoV-2-induced pathways, with 40 in clinical trials, and classifies them into viral replication and immune response mechanisms.

Inhibition of ITK differentiates GVT and GVHD in allo-HSCT

This paper shows that inhibiting ITK in donor T cells reduces GVHD while preserving GVT effects in allo-HSCT using murine models and a novel peptide inhibitor.

APOBEC3A Catalyzes Mutation and Drives Carcinogenesis In Vivo

This study shows APOBEC3A promotes tumorigenesis in mice and supports its role in causing mutations in human cancers.

A rabbit monoclonal antibody against the antiviral and cancer genomic DNA mutating enzyme APOBEC3B

This paper describes the generation and characterization of a rabbit monoclonal antibody against APOBEC3B, showing its potential as a research tool and clinical biomarker for cancer.

On the unfounded enthusiasm for soft selective sweeps II: examining recent evidence from humans, flies, and viruses

The paper evaluates three recent studies claiming pervasive soft selective sweeps in humans, flies, and viruses, finding high false-positive rates and suggesting rare soft sweeps instead.

MHC GENETIC VARIATION INFLUENCES BOTH OLFACTORY SIGNALS AND SCENT DISCRIMINATION IN RING-TAILED LEMURS

This study shows ring-tailed lemurs signal MHC diversity and similarity through genital secretions, with both sexes discriminating these signals in opposite-sex conspecifics.

Polyomavirus T-Antigen Induces APOBEC3B Expression using a LXCXE-Dependent and TP53-Independent Mechanism

This paper shows polyomavirus T-antigen induces APOBEC3B expression via the LXCXE motif without requiring TP53 inhibition, linking RB/E2F axis activation to APOBEC3B upregulation in virus-infected cells.

The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by a RNA-Mediated Dimerization Mechanism

This study identifies an RNA-mediated dimerization mechanism that regulates APOBEC3H DNA deaminase activity, localization, and antiviral function.