Structural insights into ligand efficacy and activation of the glucagon receptor
D. Hilger, K. Krishna Kumar, H. Hu, M. F. Pedersen, L. Giehm, J. M. Mathiesen, G. Skiniotis, B. K. Kobilka
The paper presents the cryo-EM structure of the glucagon receptor bound to a ligand and G-protein, revealing structural insights into ligand efficacy and activation mechanism.
bioRxiv · Jun 5, 2019 · PreprintBiophysics