Author

L. Grunewald

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

A. Eggert· 1 shared A. G. Henssen· 1 shared A. Klaus· 1 shared A. Kuenkele· 1 shared A. Vitali· 1 shared C. Caramel· 1 shared F. Hertwig· 1 shared F. Westermann· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

A. Eggert

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1 paper

Recent·Most cited

Targeting MYCN upregulates L1CAM tumor antigen in MYCN-dysregulated neuroblastoma to increase CAR T cell efficacy

L. Grunewald, L. Andersch, K. Helmsauer, S. Schwiebert, A. Klaus, A. G. Henssen, T. Straka, M. Lodrini, S. G. Wicha, S. Fuchs, F. Hertwig, F. Westermann, A. Vitali, C. Caramel, G. Buechel, , A. Kuenkele

This paper shows that high MYCN levels in neuroblastoma reduce L1CAM expression, limiting CAR T cell efficacy, and that inhibiting MYCN with MLN8237 restores L1CAM and enhances CAR T cell activity.

bioRxiv · Jan 27, 2024Immunology