Flagellin from Pseudomonas aeruginosa modulates SARS-CoV-2 infectivity in CF airway epithelial cells by increasing TMPRSS2 expression
M. Ruffin, J. Bigot, C. Calmel, J. Mercier, A. Pizzorno, M. Rosa-Calatrava, H. Corvol, V. Balloy, O. Terrier, L. Guillot
This study shows that flagellin from Pseudomonas aeruginosa increases TMPRSS2 expression in airway epithelial cells, enhancing SARS-CoV-2 infectivity, particularly in CFTR-deficient cells.
bioRxiv · Aug 24, 2020 · PreprintPathology