M. Rosa-Calatrava

Use of ANCHOR viruses to validate radiative, physical and chemical decontamination systems in operational conditions.

This paper validates ANCHOR viruses as a platform for evaluating disinfection methods across chemical, physical, and radiative modalities in operational conditions.

REAL-TIME AT-LINE MONITORING OF INFLUENZA VIRUS IN CELL CULTURE BY A SURFACE PLASMON RESONANCE BIOSENSOR

This paper develops a surface plasmon resonance biosensor for real-time monitoring of influenza virus production in cell culture, demonstrating its ability to quantify bioactive viral particles.

Preclinical evaluation of PHH-1V vaccine candidate against SARS-CoV-2 in non-human primates

This study evaluates the PHH-1V vaccine candidate against SARS-CoV-2 in non-human primates, showing high antibody levels, balanced cellular immunity, and reduced viral load.

Molnupiravir combined with different repurposed drugs further inhibits SARS-CoV-2 infection in human nasal epithelium in vitro

The paper evaluates antiviral effects of 95 single compounds and 30 combinations, showing that molnupiravir with other drugs inhibits SARS-CoV-2 replication in human nasal epithelium in vitro.

A novel effective live-attenuated human metapneumovirus vaccine candidate produced in the serum-free suspension DuckCelt-T17 cell platform

This study evaluates the use of DuckCelt-T17 avian cells for producing a live-attenuated HMPV vaccine candidate, showing its efficiency and scalability.

Flagellin from Pseudomonas aeruginosa modulates SARS-CoV-2 infectivity in CF airway epithelial cells by increasing TMPRSS2 expression

This study shows that flagellin from Pseudomonas aeruginosa increases TMPRSS2 expression in airway epithelial cells, enhancing SARS-CoV-2 infectivity, particularly in CFTR-deficient cells.

Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization

This study identifies a potent SARS-CoV-2 neutralizing antibody, 5A6, that binds bivalently to two RBDs on the spike protein, showing resistance to key mutations.

Human Respiratory Syncytial Virus-induced immune signature of infection revealed by transcriptome analysis of clinical pediatric nasopharyngeal swab samples

This study identifies an HRSV-induced immune signature in pediatric nasal wash samples using transcriptome analysis.

Transcriptional profiling of immune and inflammatory responses in the context of SARS-CoV-2 fungal superinfection in a human airway epithelial model

The paper compares the transcriptional responses of SARS-CoV-2 and Aspergillus superinfection in human airway epithelial models, identifying unique immune and inflammatory signatures.

Characterization and treatment of SARS-CoV-2 in nasal and bronchial human airway epithelia

The paper characterizes SARS-CoV-2 infection in nasal and bronchial airway epithelial models and evaluates the antiviral efficacy of remdesivir and its combination with diltiazem.

Strain-dependent impact of G and SH deletions provide new insights for live-attenuated HMPV vaccine development

This study evaluates strain-dependent effects of G and SH deletions in HMPV to inform live-attenuated vaccine development, finding that SH-deleted A1/C-85473 virus is attenuated and protective in mice.

Repurposing of drugs as novel influenza inhibitors from clinical gene expression infection signatures

This paper identifies 35 FDA-approved drugs with antiviral potential against influenza using transcriptomic signatures, validates 31 in vitro, and highlights diltiazem as a promising candidate for Phase II clinical trials.