Author

L. H. Augenlicht

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:differential expression· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

J. Choi· 2 shared A. Sacchetti· 1 shared B. van der Steen· 1 shared D. M. Huffman· 1 shared D. Seinstra· 1 shared K. Rajamaki· 1 shared K. Ye· 1 shared L. A. Aaltonen· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

J. Choi

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Author profile →

2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 2, 2023

The origin of intestinal cancer in the context of inflammation

M. P. Verhagen, R. Joosten, M. Schmitt…·R. Fodde

The paper shows that secretory cell lineages, not stem cells, can trigger tumor formation in the context of inflammation and Western-style diets, which are major colon cancer risk factors.

DOI 10.1101/2023.10.02.560432

mousebulk RNA-seq

𝕏 PostBluesky

Cell BiologybioRxivPreprintAug 31, 2022

Intestinal stem cell aging at single-cell resolution: functional perturbations alter cell developmental trajectory reversed by gerotherapeutics

J. Choi, M. Houston, R. Wang…·L. H. Augenlicht

This study uses single-cell RNA sequencing to show that aging impairs intestinal stem cell maturation, which is reversed by metformin and rapamycin.

DOI 10.1101/2022.08.31.505869

mousescRNA-seq

𝕏 PostBluesky