L. I. Leichert

This paper investigates how auranofin affects Gram-positive and Gram-negative bacteria, finding that Gram-negative bacteria are more resistant due to efflux systems and glutathione levels.

This study shows auranofin forms S-Au-S bonds between cysteine thiols in proteins, independent of thioredoxin reductase, suggesting a new mechanism for its antibacterial activity.

This study investigates the role of glutathione in periplasmic redox homeostasis and oxidative protein folding in E. coli using genetically encoded redox probes.

This paper identifies a temperature-regulated RNA thermometer in the katY gene of Yersinia pseudotuberculosis that enhances KatY expression at host body temperature, providing protection against oxidative stress.

This study identifies specific chlorinated residues in RidA that are critical for its chaperone activity under oxidative stress.

This study identifies mtROS-sensitive processes in activated CD4+ T cells by analyzing cysteine oxidation and reduction, revealing novel thiol switches and zinc-dependent regulatory mechanisms.

This study shows that N-chlorination of plasma proteins by HOCl converts them into chaperones and immune activators, with implications for neutrophil survival and inflammation.