A cell competition-based drug screen identifies a novel compound that induces dual c-Myc depletion and p53 activation
D. S. Tadele, J. M. Robertson, R. Crispin, M. C. Herrera, M. Chlubnova, L. I. Piechaczyk, P. Ayuda-Duran, S. K. Singh, T. Gedde-Dahl, Y. Floisand, J. Skavland, J. Wesche, B.-T. Gjertsen, J. M. Enserink
This study identifies a novel compound, DJ34, that depletes c-Myc and activates p53, showing strong activity against leukemic stem cells across multiple cancer types.
bioRxiv · May 16, 2020 · PreprintCancer Biology