S. K. Singh

Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response via AP1 dichotomy in pancreatic cancer

The paper identifies AP1 transcription factor dichotomy and CD68+ macrophages as drivers of intratumoral subtype co-existence and therapy response in pancreatic cancer.

Chimeric oncolytic adenovirus evades neutralizing antibodies from human patients and exhibits enhanced anti-glioma efficacy in immunized mice

This paper develops a chimeric oncolytic adenovirus that evades neutralizing antibodies and shows improved anti-glioma efficacy in mice.

The Non-Phototrophic Hypocotyl3 (NPH3)-domain protein NRL5 is a trafficking-associated GTPase essential for drought resistance.

The paper identifies NRL5, an NPH3-domain protein with GTPase activity, as essential for drought resistance by regulating proline catabolism and trafficking interactions.

Novel Function of Transcription Factor TTF1 in UV Mediated DNA Damage Repair in Mammalian Cells

This study identifies TTF1 as an interactor of DDB1 and shows its role in UV-induced DNA damage repair through co-localization with γH2AX and reciprocal regulation of DDB1 levels.

miR-17~92 Suppresses Proliferation and Invasion of Cervical Cancer Cells by Inhibiting Cell Cycle Regulator Cdt2

Biophysical Characterization of an Essential Mammalian Protein; Transcription Termination Factor I (TTF1)

This paper characterizes the biophysical properties of a truncated TTF1 protein using multiple techniques, revealing its helical structure and molecular size.

Characterization of the minimal residual disease state reveals distinct evolutionary trajectories of human glioblastoma

This study characterizes the minimal residual disease state in glioblastoma, revealing distinct evolutionary trajectories and immunomodulatory signatures associated with recurrence.

Developing selective FPR2 agonists can be a potential approach to treat moderate to severe asthma.

The paper develops selective FPR2 agonists and shows they reduce non-resolving inflammation in asthma models.

The nuclear effector ArPEC25 from the necrotrophic fungus Ascochyta rabiei targets the chickpea transcription factor CaβLIM1a and negatively modulates lignin biosynthesis for host susceptibility

The Ascochyta rabiei effector ArPEC25 enters the host nucleus and targets the transcription factor CaβLIM1a to manipulate phenylpropanoid pathway for negative modulation of chickpea lignin biosynthesis.

Hitting more birds with one stone: CD70 as an actionable immunotherapeutic target in recurrent glioblastoma

This study identifies CD70 as a therapeutic target for recurrent glioblastoma, showing that CD70 knockdown reduces tumorigenicity and CD70 CAR-T therapy improves survival in animal models.

Recombinant binder of sperm protein1 (rec-BSP1) as a potent fertility factor mediates its effect on embryo production

This study optimizes the production of rec-BSP1 and demonstrates its ability to enhance buffalo sperm motility and blastocyst production in vitro.

PRAK-03202: A triple antigen VLP vaccine candidate against SARS CoV-2

This paper develops a triple antigen VLP vaccine candidate, PRAK-03202, against SARS-CoV-2 and shows it induces neutralizing antibodies and Th1 immune responses in mice.

New insights on species divergence in red panda

The paper identifies the Siang river as a potential boundary for divergence between two red panda species using Bayesian phylogeny and MJ network analysis.

Integrated genomic view of SARS-CoV-2 in India

The paper analyzes SARS-CoV-2 genomic data from India to trace introduction and local transmission, identifying multiple clades and highlighting the need for molecular surveillance.

Multi-Antigenic Virus-like Particle of SARS CoV-2 produced in Saccharomyces cerevisiae as a vaccine candidate

The paper reports the production of a multi-antigenic SARS CoV-2 virus-like particle (VLP) in Saccharomyces cerevisiae as a vaccine candidate, confirmed by TEM and analytical data.

A cell competition-based drug screen identifies a novel compound that induces dual c-Myc depletion and p53 activation

This study identifies a novel compound, DJ34, that depletes c-Myc and activates p53, showing strong activity against leukemic stem cells across multiple cancer types.

Latent defense response to non-pathogenic microbial factors impairs plant-rhizobacteria mutualism

A hidden layer of host immunity against non-pathogenic microbes leads to plant incompatibility with beneficial rhizobacteria.

Size and mass prediction of almond kernels using machine learning image processing

This study uses image processing and machine learning to accurately predict almond kernel size and mass with low error rates.

Structure and activation mechanism of the BBSome membrane-protein trafficking complex

The paper reports cryo-EM structures of the BBSome in inactive and active states, revealing how ARL6 binding activates the complex and how disease mutations disrupt its function.

A Novel Chloroplast Super-Complex Consisting of the ATP Synthase and Photosystem I Reaction Center

The paper identifies a novel chloroplast super-complex containing ATP synthase and photosystem I in the non-appressed stromal domain of thylakoid membranes.

Signature activities of 20S proteasome include degradation of the ubiquitin-tag with the protein under hypoxia

The paper identifies the 20S proteasome's ability to degrade ubiquitin-tagged proteins under hypoxia and shows its role in improving cell survival.

Machine learnt image processing to predict weight and size of rice kernels

This study uses machine learning and image processing to predict rice kernel size and mass with high accuracy, improving rice quality assessments.

PTY 2 As DPP-IV Inhibitor Prevents Intestinal Cell’s Apoptosis

PTY-2, a DPP-IV inhibitor, reduces intestinal cell apoptosis in diabetic rats by upregulating SOD and downregulating DPP-IV mRNA expression.

Anti-oxidant, anti-apoptotic, anti-hypoxic and anti-inflammatory conditions induced by PTY-2 against STZ-induced stress in islets

This study investigates the protective effects of PTY-2 against STZ-induced pancreatic stress in rats, showing it modulates key inflammatory, apoptotic, and oxidative stress markers.

Larval growth and survival in Indian Butter Catfish, Ompok bimaculatus (Bloch): effect of light intensity and photoperiod

This study examines how light intensity and photoperiod affect growth and survival of Ompok bimaculatus larvae, finding optimal conditions for growth and survival.

p53 dynamically directs TFIID assembly on target gene promoters

This study shows p53 dynamically facilitates TFIID assembly on target promoters through DNA binding and conformational changes.