Author

L. J. Friedman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Assay:fluorescence / live-cell microscopy· 4 Organism:E. coli· 3 Approach:microscopy & imaging analysis· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:Bayesian inference· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. Gelles· 6 shared D. Tenenbaum· 2 shared J. Kondev· 2 shared K. Inlow· 2 shared A. Cai· 1 shared C. Ramsoomair· 1 shared D. Theobald· 1 shared G. A. Rosen· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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6 shared papersBiophysics

J. Gelles

Mutual co-authors in cluster

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6 papers

Recent·Most cited

Recycling of Bacterial RNA Polymerase by the Swi2/Snf2 ATPase RapA

K. Inlow, D. Tenenbaum, L. J. Friedman, J. Kondev, J. Gelles

This study uses single-molecule fluorescence microscopy to show RapA removes RNA polymerase from DNA after termination via ATP hydrolysis, enabling RNAP recycling in E. coli.

bioRxiv · Mar 22, 2023Biophysics

RNA polymerase sliding on DNA can couple the transcription of nearby bacterial operons

D. Tenenbaum, K. Inlow, L. J. Friedman, A. Cai, J. Gelles, J. Kondev

This study shows that RNA polymerase can reinitiate transcription of nearby bacterial operons after sliding along DNA, demonstrating efficient coupling over distances up to 1,000 bp.

bioRxiv · Feb 10, 2023Biophysics

Bayesian machine learning analysis of single-molecule fluorescence colocalization images

Y. A. Ordabayev, L. J. Friedman, J. Gelles, D. Theobald

The paper introduces a Bayesian machine learning method for analyzing single-molecule fluorescence colocalization images, improving accuracy by accounting for uncertainties in image data.

bioRxiv · Sep 30, 2021Biophysics

DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7

L. De Jesus Kim, L. J. Friedman, C. Ramsoomair, J. Gelles, S. P. Bell

The paper shows DDK controls Cdc45-GINS binding multiplicity to Mcm2-7, affecting CMG formation and replication initiation.

bioRxiv · Dec 9, 2020Cell Biology

Dynamics of RNA polymerase II and elongation factor Spt4/5 recruitment during activator-dependent transcription

G. A. Rosen, I. Baek, L. J. Friedman, Y. J. Joo, S. Buratowski, J. Gelles

This study uses single-molecule fluorescence microscopy to analyze the dynamics of RNA polymerase II and Spt4/5 recruitment during activator-dependent transcription in yeast.

bioRxiv · Jun 1, 2020Biochemistry

Mechanism of upstream promoter element stimulation of transcription at a ribosomal RNA promoter determined by single-molecule imaging

J. P. Mumm, L. J. Friedman, J. Gelles

This study uses single-molecule imaging to reveal how the UP element enhances transcription initiation at the E. coli 16s rRNA promoter by increasing polymerase binding rates.

bioRxiv · Feb 17, 2020 · PreprintBiochemistry