The MS remyelinating drug bexarotene (an RXR agonist) promotes induction of human Tregs and suppresses Th17 differentiation in vitro
C. M. Gaunt, D. Rainbow, R. MacKenzie, L. Jarvis, H. Mousa, N. Cunniffe, Z. Georgieva, W. Brown, A. Coles, J. L. Jones
This study shows bexarotene, an RXR agonist, promotes Treg induction and suppresses Th17 differentiation in human CD4 T cells, independent of tRA and RAR signaling.
bioRxiv · Feb 17, 2021Immunology