Author

J. L. Jones

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 8 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 9 Research Focus:cell type annotation· 7 Approach:experimental assay· 7 Assay:flow cytometry· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:differential expression· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

L. B. Jarvis· 5 shared D. Rainbow· 4 shared K. Saeb-Parsy· 4 shared O. Suchanek· 3 shared Z. Georgieva· 3 shared A. Prabhu· 2 shared C. Xu· 2 shared D. B. Rainbow· 2 shared

Activity by Year

2016-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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5 shared papersImmunology

L. B. Jarvis

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Circulating CD4 regulatory T cells are broadly preserved in Parkinson's disease despite altered HELIOS expression

Sara C Crooks, A. Prabhu, L. B. Jarvis, Z. G. Georgieva, D. B. Rainbow, C. H. Williams-Gray, J. L. Jones

This study examines circulating CD4 regulatory T cells in Parkinson's disease and finds they are largely preserved in phenotype and function, though show reduced HELIOS expression in naive subsets.

bioRxiv · Nov 9, 2026 · PreprintImmunology

Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age

S. B. Wells, D. Rainbow, M. Mark, P. P. A. S. Szabo, C. Ergen, A. R. Maceiras, D. P. Caron, E. Rahmani, E. Benuck, V. V. P. Amiri, D. Chen, A. Wagner, S. K. Howlett, L. B. Jarvis, K. L. Elli, , N. Yosef

The paper profiles immune cell RNA and protein expression across tissues and age to identify tissue-specific and age-related immune signatures.

Nature Immunology · Aug 13, 2025Peer-reviewedImmunology

34-parameter full spectrum immunophenotyping panel of human regulatory and effector lymphocytes

Z. Georgieva, V. Coppard, J. H. Yang, R. Grenfell, J. L. Jones

This paper introduces a 34-marker flow cytometry panel for comprehensive immunophenotyping of regulatory and effector lymphocytes in human samples.

bioRxiv · Mar 21, 2024 · PreprintImmunology

Hiding in Plain Sight: Thymic CD8+FOXP3+Tregs sequester CD25 and are enriched in human tissues

L. B. Jarvis, S. K. Howlett, D. Rainbow, V. Coppard, R. Ferreira, E. Needham, A. Prabhu, S. Alkwai, L. Ellis, Z. Georgieva, O. Suchanek, H. S. Mousa, K. T. Mahbubani, K. Saeb-Parsy, L. S. Wicker, J. L. Jones

The paper identifies CD8+FOXP3+ Tregs enriched in human tissues, expressing intracellular CD25 and tissue residency markers, and demonstrates their therapeutic potential and association with disease states.

bioRxiv · Dec 24, 2023 · PreprintImmunology

Cross-tissue immune cell analysis reveals tissue-specific adaptations and clonal architecture across the human body

C. Dominguez Conde, T. Gomes, L. B. Jarvis, C. Xu, S. Howlett, D. Rainbow, O. Suchanek, H. King, L. Mamanova, K. Polanski, N. Huang, E. Fasouli, K. Mahbubani, M. Prete, E. Tuck, , S. A. Teichmann

The paper analyzes immune cell diversity across 15 human tissues using single-cell RNA sequencing and VDJ sequencing, revealing tissue-specific features and clonal architecture of T and B cells.

bioRxiv · Apr 28, 2021Immunology

The MS remyelinating drug bexarotene (an RXR agonist) promotes induction of human Tregs and suppresses Th17 differentiation in vitro

C. M. Gaunt, D. Rainbow, R. MacKenzie, L. Jarvis, H. Mousa, N. Cunniffe, Z. Georgieva, W. Brown, A. Coles, J. L. Jones

This study shows bexarotene, an RXR agonist, promotes Treg induction and suppresses Th17 differentiation in human CD4 T cells, independent of tRA and RAR signaling.

bioRxiv · Feb 17, 2021Immunology

Distinct microbial and immune niches of the human colon

K. R. James, T. Gomes, R. Elmentaite, N. Kumar, E. L. Gulliver, H. W. King, M. D. Stares, B. R. Bareham, J. R. Ferdinand, V. Petrova, K. Polanski, S. C. Forster, L. B. Jarvis, O. Suchanek, S. Howlett, , S. A. Teichmann

The paper examines microbial and immune cell interactions in the human colon, identifying distinct immune niches and T cell profiles along the colon.

bioRxiv · Dec 12, 2019Immunology

Subcellular mRNA localization regulates ribosome biogenesis in migrating cells

M. Dermit, M. Dodel, F. C. Y. Lee, M. S. Azman, H. Schwenzer, J. L. Jones, S. P. Blagden, J. Ule, F. K. Mardakheh

The paper shows that subcellular localization of RP-mRNAs via LARP6 enhances ribosome biogenesis during cell migration and supports cancer progression through EMT.

bioRxiv · Dec 2, 2019Cell Biology

Recent thymic emigrants produce antimicrobial IL-8, express complement receptors and are precursors of a tissue-homing Th8 lineage of memory cells

M. L. Pekalski, A. Rubio Garcia, R. C. Ferreira, D. B. Rainbow, D. J. Smyth, M. Mashar, J. Brady, N. Savinykh, X. Castro Dopico, S. Mahmood, S. Duley, H. E. Stevens, N. M. Walker, A. J. Cutler, F. Waldron-Lynch, , L. S. Wicker

The paper identifies CR2+ naive T cells as recent thymic emigrants that express antimicrobial IL-8 and complement receptors, and may become tissue-homing memory cells.

bioRxiv · Jun 17, 2016Immunology