Phosphodiesterase 5 inhibition improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure.
M. Lawless, J. L. Caldwell, E. J. Radcliffe, C. E. R. Smith, G. W. Madders, D. C. Huthchings, L. S. Woods, S. J. Church, R. D. Unwin, G. J. Kirkwood, L. K. Becker, C. M. Pearman, R. F. Taylor, D. A. Eisner, K. M. Dibb, A. W. Trafford
This study shows that tadalafil improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure using a sheep model.
bioRxiv · Apr 2, 2019Physiology