Author

C. E. R. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Physiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Assay:electrophysiology· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

J. L. Caldwell· 4 shared A. W. Trafford· 3 shared D. A. Eisner· 3 shared K. M. Dibb· 3 shared C. J. Quinn· 2 shared C. M. Pearman· 2 shared C. Pinali· 2 shared E. J. Radcliffe· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersPhysiology

J. L. Caldwell

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4 papers

Recent·Most cited

Chronic nicotine exposure is associated with electrophysiological and sympathetic remodeling in the intact rabbit heart

A. Guevara, C. E. R. Smith, J. L. Caldwell, L. Ngo, L. R. Mott, I.-J. Lee, S. Tapa, Z. Wang, L. Wang, W. R. Woodward, G. A. Ng, B. A. Habecker, C. M. Ripplinger

This study shows chronic nicotine exposure in rabbits increases heart rate, lowers alternans threshold, and reduces sympathetic responses, likely due to hypo-innervation and diminished β-adrenergic responsiveness.

bioRxiv · Nov 23, 2023Physiology

Atrial t-tubules adopt a specialist developmental state while alterations to Ca2+ buffering maintain systolic Ca2+ during postnatal development

C. E. R. Smith, J. D. Clarke, C. J. Quinn, Z. Sultan, H. Najem, N. C. Denham, D. C. Hutchings, G. W. P. Madders, J. L. Caldwell, L. K. Toms, C. Pinali, D. A. Eisner, A. W. Trafford, K. M. Dibb

This study examines atrial t-tubule development in sheep, showing that despite reduced density in newborns, Ca2+ handling is maintained through increased L-type Ca2+ current and sarcoplasmic reticulum content.

bioRxiv · Oct 1, 2023 · PreprintPhysiology

Disordered yet functional atrial t-tubules on recovery from heart failure

J. L. Caldwell, J. D. Clarke, C. E. R. Smith, C. Pinali, C. J. Quinn, C. M. Pearman, A. Adomaviciene, E. J. Radcliffe, A. E. Watkins, M. A. Horn, E. F. Bode, M. Eisner, D. A. Eisner, A. W. Trafford, K. M. Dibb

This study shows that atrial t-tubules and systolic Ca2+ recovery are restored after heart failure in sheep, with myotubularin playing a key role in this process.

bioRxiv · Oct 28, 2021 · PreprintPhysiology

Phosphodiesterase 5 inhibition improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure.

M. Lawless, J. L. Caldwell, E. J. Radcliffe, C. E. R. Smith, G. W. Madders, D. C. Huthchings, L. S. Woods, S. J. Church, R. D. Unwin, G. J. Kirkwood, L. K. Becker, C. M. Pearman, R. F. Taylor, D. A. Eisner, K. M. Dibb, A. W. Trafford

This study shows that tadalafil improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure using a sheep model.

bioRxiv · Apr 2, 2019Physiology