β-catenin-Mediated Wnt Signal Transduction Proceeds Through an Endocytosis-Independent Mechanism
E. Y. Rim, L. K. Kinney, R. Nusse
This study investigates whether endocytosis is required for Wnt signal transduction by disrupting endocytic pathways in mouse embryonic stem cells and finding no effect on β-catenin nuclear translocation or target gene transcription.
bioRxiv · Feb 13, 2020Cell Biology