Independent human mesenchymal stromal cell-derived extracellular vesicle preparations differentially affect symptoms in an advanced murine Graft-versus-Host-Disease model
R. J. Madel, V. Börger, R. Dittrich, M. Bremer, T. Tertel, N. Ngo Thi Phuong, H. A. Babo, L. Kordelas, J. Buer, P. A. Horn, A. M. Westendorf, S. Brandau, C. J. Kirschning, B. Giebel
The paper shows that different human MSC-derived EV preparations have varying therapeutic effects in a murine GvHD model, emphasizing the need for potency evaluation before clinical use.
bioRxiv · Dec 21, 2020 · PreprintCell Biology