T. Tertel

Single extracellular vesicle analysis performed by imaging flow cytometry in contrast to NTA rigorously assesses the accuracy of urinary extracellular vesicle preparation techniques

The paper compares urinary extracellular vesicle preparation methods using NTA and IFCM, finding that NTA overestimates particle yield and correlates with contaminant proteins rather than true EV markers.

Independent human mesenchymal stromal cell-derived extracellular vesicle preparations differentially affect symptoms in an advanced murine Graft-versus-Host-Disease model

The paper shows that different human MSC-derived EV preparations have varying therapeutic effects in a murine GvHD model, emphasizing the need for potency evaluation before clinical use.