tRNA modifications tune decoding of codon pairs to prevent cellular quality control responses
J. Wu, C. Eggers, O. Sin, L. Koziej, H. Mancilla, F. Mollet, H. R. Scholer, H. C. Drexler, T. Ranff, C. Fufezan, C. Kraft, S. Glatt, J. M. Bruder, S. A. Leidel
This study shows that tRNA modifications affect codon pair decoding, leading to ribosome stalling and triggering quality control responses to prevent protein aggregation.
bioRxiv · Feb 27, 2024 · PreprintBiochemistry