Within-host evolutionary dynamics and tissue compartmentalization during acute SARS-CoV-2 infection
M. Farjo, K. Koelle, M. A. Martin, L. L. Gibson, K. K. Walden, G. Rendon, C. J. Fields, F. Alnaji, N. Gallagher, C. H. Luo, H. H. Mostafa, Y. C. Manabe, A. Pekosz, R. L. Smith, D. D. McManus, C. B. Brooke
This study uses daily saliva and nasal samples to track SARS-CoV-2 genetic variants in infected individuals, revealing stochastic evolution, mutational hotspots, and compartmentalization between sample sites.
bioRxiv · Jun 21, 2022Microbiology