Single Cell RNA-Seq Analysis of Regenerative Drug-Treated Human Pancreatic Islets Identifies A Cycling Alpha Cell Population As Key Beta Cell Progenitors
E. Karakose, X. Wang, P. Wang, S. Carcamo, D. Demircioglu, O. Wood, R. Kang, L. Lambertini, G. Lu, D. K. Scott, A. Garcia-Ocana, C. Argmann, R. Sebra, D. Hasson, A. F. Stewart
This study uses single-cell RNA sequencing to identify cycling alpha cells as key beta cell progenitors in response to DYRK1A inhibitor treatment in human pancreatic islets.
bioRxiv · Sep 7, 2023 · PreprintCell Biology