A. Garcia-Ocana

LGR4 is essential for maintaining beta-cell homeostasis through suppression of RANK

This study shows LGR4 maintains beta-cell health by suppressing RANK, with effects observed in both in vitro and mouse models under stress and aging.

Human Pancreatic α-Cell Heterogeneity and Trajectory Inference Analysis Using Integrated Single Cell- and Single Nucleus-RNA Sequencing Platforms

This study identifies human α-cell and β-cell subtypes and trajectories using integrated scRNA-seq and snRNA-seq, revealing gene signatures for interconversion and highlighting in vivo transitions in T2D.

Single Cell RNA-Seq Analysis of Regenerative Drug-Treated Human Pancreatic Islets Identifies A Cycling Alpha Cell Population As Key Beta Cell Progenitors

This study uses single-cell RNA sequencing to identify cycling alpha cells as key beta cell progenitors in response to DYRK1A inhibitor treatment in human pancreatic islets.

Magnetogenetic cell activation using endogenous ferritin

This paper develops a magnetogenetic method using anti-ferritin nanobodies and a benchtop electromagnet to activate cells in vivo, improving glucose tolerance in mice.

Single Nucleus RNA Sequencing of Human Pancreatic Islets In Vitro and In Vivo Identifies New Gene Sets and Three β-Cell Subpopulations with Different Transcriptional Profile

This study compares scRNA-seq and snRNA-seq of human pancreatic islets, identifying new gene markers and three β-cell subpopulations with distinct transcriptional profiles.

Nrf2 Regulates β-cell Mass by Suppressing Cell Death and Promoting Proliferation

This study shows that Nrf2 regulates β-cell mass by reducing cell death and enhancing proliferation, suggesting it as a therapeutic target for diabetes.

Human Beta Cell Mass Expansion In Vivo With A Harmine and Exendin-4 Combination: Quantification and Visualization By iDISCO+ 3D Imaging

This study shows a combination of DYRK1A inhibitor and GLP1R agonist increases human beta cell mass in vivo by 400-700% in mice, using iDISCO+ 3D imaging for quantification.

Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variant.

This study investigates the impact of a GIPR variant on glucose homeostasis using a mouse model, finding altered intracellular trafficking and increased GIP sensitivity.

Human pseudoislet system enables detection of differences in G-protein-coupled-receptor signaling pathways between α and β cells

The paper develops a pseudoislet system to study GPCR signaling differences between human α and β cells, showing distinct effects of Gi and Gq pathway activations on hormone secretion.