Tissue architecture dynamics underlying immune development and decline in the thymus
Sophia Liu, Mirco Friedrich, Ruth Raichur, Dennis H. Gong, Niklas Kehl, Qiyu Gong, Bingxian Chen, Karin Gustafsson, L. Larissa, David T. Scadden, Rhiannon K. Macrae, Feng Zhang, Fei Chen
This study uses spatial transcriptomics and TCR sequencing in mice to analyze thymus changes across lifespan, revealing structural and transcriptional alterations linked to immune decline.
bioRxiv · Jun 28, 2025 · PreprintImmunology