Dennis H. Gong

GLIS3 Marks a Neural-like Progenitor Cell State that Drives Metastasis in Pancreatic Ductal Adenocarcinoma

This study identifies Glis3 as a key transcription factor driving metastasis in PDAC by promoting a neural-like progenitor cell state.

Cross-species single-cell atlases chart progression, therapy-driven remodelling and immune evasion in pancreatic cancer

This paper generates cross-species single-cell atlases of pancreatic cancer to study progression, therapy response, and immune evasion across human and mouse models.

Integrated spatial morpho-transcriptomics predicts functional traits in pancreatic cancer

The paper integrates spatial morpho-transcriptomics to identify morphological subtypes in pancreatic cancer cell lines and tissues, linking them to gene expression, drug resistance, and metastatic potential.

The Pdgfd-Pdgfrb axis orchestrates tumor-nerve crosstalk in pancreatic cancer

This study identifies Pdgfd-Pdgfrb signaling as a driver of perineural invasion in pancreatic cancer by promoting cancer cell invasiveness and nerve engagement.

Tissue architecture dynamics underlying immune development and decline in the thymus

This study uses spatial transcriptomics and TCR sequencing in mice to analyze thymus changes across lifespan, revealing structural and transcriptional alterations linked to immune decline.

Pan-Cancer Biomarker Analysis from the Cancer Dependency Map: A Blueprint for Precision Oncology

This study analyzes cancer dependency maps across 1,150 molecular profiles to identify biomarkers for patient stratification and therapeutic response prediction.