Rhiannon K. Macrae

TIGRFinder annotated 6,685 TIGR arrays; cryo-EM structures show inactive RuvC domains, and E. coli reporter assays show CsTasR and MbTasA repress transcription in a guide-dependent manner.

This paper demonstrates the use of in vitro-assembled Drosophila Arc1 capsids to deliver gene editors to dystrophic muscle, achieving exon skipping and dystrophin restoration in mdx mice.

This study uses spatial transcriptomics and TCR sequencing in mice to analyze thymus changes across lifespan, revealing structural and transcriptional alterations linked to immune decline.