Author

L. M. Haynes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

A. Yee· 2 shared C. A. Kretz· 2 shared D. Ginsburg· 2 shared D. R. Siemieniak· 2 shared Z. M. Huttinger· 2 shared D. A. Lawrence· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

A. Yee

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2 papers

Recent·Most cited

Deep mutational scanning and massively parallel kinetics of plasminogen activator inhibitor-1 functional stability

L. M. Haynes, Z. M. Huttinger, A. Yee, C. A. Kretz, D. R. Siemieniak, D. A. Lawrence, D. Ginsburg

The paper analyzes PAI-1 variants to identify mutations that increase functional stability and inhibitory activity, and develops a method to measure functional half-lives of hundreds of variants in parallel.

bioRxiv · Jul 19, 2022 · PreprintBiochemistry

Deep mutational scanning of the plasminogen activator inhibitor-1 functional landscape

Z. M. Huttinger, L. M. Haynes, A. Yee, C. A. Kretz, D. R. Siemieniak, D. Ginsburg

The paper uses deep mutational scanning to assess the functional impact of amino acid substitutions in PAI-1, identifying variants that disrupt its inhibitory activity against uPA.

bioRxiv · Apr 15, 2021Biochemistry