Progerin-Expressing Endothelial Cells are Unable to Adapt to Shear Stress
B. E. Danielsson, H. C. Peters, K. Bathula, L. M. Spear, N. A. Noll, K. N. Dahl, D. E. Conway
This study shows that progerin-expressing endothelial cells and those with ZMPSTE24 knockdown cannot adapt to shear stress, leading to cell loss, while wild-type lamin A overexpression also impairs adaptation.
bioRxiv · Aug 20, 2021Biophysics