PRMT5 in T helper lymphocytes is essential for cholesterol biosynthesis-mediated Th17 responses and autoimmunity
L. M. Webb, S. Sengupta, C. Edell, S. A. Amici, J. Narvaez-Miranda, A. Kennemer, M. Guerau-de-Arellano
This study shows PRMT5 is essential for Th17 differentiation and autoimmunity by enhancing cholesterol biosynthesis and ROR-gamma t activation.
bioRxiv · Oct 3, 2019 · PreprintImmunology