L. M. Williams

Diversification of Transcription Factor NF-κB in Protists

This paper functionally characterizes NF-κB in protists, showing its structural and regulatory diversity and evolutionary origins outside of metazoans.

α1A-adrenoceptor inverse agonists and agonists modulate receptor signalling through a conformational selection mechanism

This study shows how different ligands modulate the conformational states of the α1A-adrenoceptor through a conformational selection mechanism, as revealed by NMR analysis of labeled receptor mutants.

Transcription factor NF-κB in a basal metazoan, the sponge, has conserved and unique sequences, activities, and regulation

This study characterizes the NF-κB protein in the sponge Amphimedon queenslandica, showing conserved features with vertebrates but distinct regulatory mechanisms.