Bile acid-CoA:amino acid N-acyltransferase gene knockout alters early life development, the gut microbiome and reveals unusual bile acid conjugates in mice
K. A. Neugebauer, D. V. Guzior, J. Feiner, M. Rzepka, A. Schillmiller, S. O'Reilly, A. D. Jones, V. E. Watson, J. P. Luyendyk, L. McCabe, R. A. Quinn
This study shows that BAAT gene deletion in mice leads to altered bile acid conjugation, microbiome changes, and unusual bile acid conjugates, with potential rescue by other enzymes.
bioRxiv · Apr 10, 2022 · PreprintMicrobiology