R. A. Quinn

Bile acid-CoA:amino acid N-acyltransferase gene knockout alters early life development, the gut microbiome and reveals unusual bile acid conjugates in mice

This study shows that BAAT gene deletion in mice leads to altered bile acid conjugation, microbiome changes, and unusual bile acid conjugates, with potential rescue by other enzymes.

Gut metabolites are more predictive of disease- and cohoused- states than gut bacterial features in a mouse model of polycystic ovary syndrome

This study shows gut metabolites, especially bile acids, better predict PCOS-like disease and cohousing effects than gut bacteria in a mouse model.

Metabolomic signatures of coral bleaching history

This study identifies metabolomic signatures linked to coral bleaching history, showing that prior bleaching affects both coral and algal biochemistry and influences thermal stress responses.

The Molecular and Microbial Microenvironments in Chronically Diseased Lungs

The paper generates 3D maps of microbiomes and metabolomes in cystic fibrosis lungs, revealing personalized and regiospecific chemical environments and microbial interactions.

Chemical Impacts of the Microbiome Across Scales Reveal Novel Conjugated Bile Acids

The paper identifies novel conjugated bile acids produced by the microbiome in mice and humans using mass spectrometry and a murine 3D model.