Assessing risks and mechanisms of idiosyncratic drug toxicity by fingerprints of cell signaling responses.
A. Medvedev, S. Makarov, L. Medvedeva, E. Martsen, K. Gorman, B. Lin, S. S. Makarov
The paper assesses idiosyncratic drug toxicity by analyzing cell signaling responses, finding that drugs with smaller safety margins are more likely to cause liver injury.
bioRxiv · Dec 1, 2022 · PreprintPharmacology & Toxicology