Author

L. Michalak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 2 Assay:metagenomics· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

B. Westereng· 3 shared L. J. Lindstad· 2 shared P. B. Pope· 2 shared S. A. Leivers· 2 shared S. L. La Rosa· 2 shared A. K. Rohr· 1 shared A. R. Kjendseth· 1 shared B. Henrissat· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMicrobiology

B. Westereng

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Author profile →

3 papers

Recent·Most cited

Human gut Faecalibacterium prausnitzii deploy a highly efficient conserved system to cross-feed on β-mannan-derived oligosaccharides

L. J. Lindstad, G. Lo, S. A. Leivers, Z. Lu, L. Michalak, G. Vasconcelos Pereira, A. K. Rohr, E. Martens, L. S. McKee, S. Duncan, B. Westereng, P. B. Pope, S. L. La Rosa

This study identifies a conserved system in Faecalibacterium prausnitzii that enables efficient cross-feeding on β-mannan-derived oligosaccharides, enhancing butyrate production in the human gut.

bioRxiv · Dec 23, 2020Microbiology

Microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut.

L. Michalak, J. C. Gaby, L. Lagos, S. L. La Rosa, T. R. Hvidsten, C. Tetard-Jones, W. G. T. Willats, N. Terrapon, V. Lombard, B. Henrissat, J. Droge, M. Arntzen, L. H. Hagen, M. Overland, P. B. Pope, B. Westereng

This study shows that a tailored acetylated galactoglucomannan fibre selectively activates butyrate-producing gut bacteria and triggers secondary metabolic shifts in neighboring microbial populations in pigs.

bioRxiv · Aug 14, 2020 · PreprintMicrobiology

A pair of esterases from a commensal gut bacterium remove acetylations from all positions on complex β-mannans

L. Michalak, S. Leanti La Rosa, S. A. Leivers, L. J. Lindstad, A. R. Kjendseth, F. L. Aachmann, B. Westereng

This paper identifies two esterases from a gut bacterium that cooperatively deacetylate complex β-mannans, revealing their structural and functional mechanisms.

bioRxiv · Oct 1, 2019Biochemistry