CagY-dependent regulation of type IV secretion in Helicobacter pylori is associated with alterations in integrin binding
E. Skoog, V. A. Morikis, M. E. Martin, G. A. Foster, L. P. Cai, L. M. Hansen, B. Li, J. A. Gaddy, S. Simon, J. V. Solnick
This study shows that recombination in the CagY MRR of H. pylori modulates T4SS function by altering binding to 5β1 integrin, which affects host inflammatory responses and bacterial colonization.
bioRxiv · Apr 4, 2018Microbiology