Unveiling the multi-step solubilization mechanism of single vesicles by detergents.
P. A. Dalgarno, J. Juan-Colas, G. J. Hedley, L. Pineiro, M. Novo, C. Perez-Gonzalez, I. D. W. Samuel, M. C. Leake, S. Johnson, W. Al-Soufi, J. C. Penedo, S. D. Quinn
This study uses svFRET to reveal the biphasic solubilization kinetics of vesicles by detergents, identifying an initial fast swelling step followed by slow lipid loss and micellization.
bioRxiv · May 15, 2019Biophysics