Author

C. Perez-Gonzalez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Cancer Biology· 2 Biophysics· 1 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Approach:microscopy & imaging analysis· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:development & morphogenesis· 2 Assay:imaging· 2

Frequent Co-Authors

X. Trepat· 4 shared D. M. Vignjevic· 2 shared D. Matic Vignjevic· 2 shared J. Barbazan· 2 shared M. Gomez-Gonzalez· 2 shared A. A. Khalil· 1 shared A. Alvarez-Varela· 1 shared A. Cazares· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersCell Biology

X. Trepat

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Aging and freezing of active nematic dynamics of cancer-associated fibroblasts by fibronectin matrix remodeling

C. Jacques, L. Perrin, J. Ackermann, S. Bell, O. Zajac, A. Lapierre, L. Anger, C. Hallopeau, C. Perez-Gonzalez, L. Balasubramaniam, X. Trepat, B. Ladoux, A. Maitra, R. Voituriez, D. Matic Vignjevic

This study investigates how fibronectin matrix remodeling by cancer-associated fibroblasts (CAFs) influences their nematic dynamics, revealing aging and freezing of defect motion in the ECM.

bioRxiv · Nov 22, 2023Cell Biology

Mechanical regulation of cell fate transitions underlying colorectal cancer metastasis formation

M. C. van der Net, M. J. Vliem, L. J. S. Kemp, C. Perez-Gonzalez, E. A. Strating, A. Krotenberg-Garcia, R. M. Houtekamer, K. B. van den Anker, J. L. Monster, H. J. G. Snippert, A. A. Khalil, J. van Rheenen, S. J. Suijkerbuijk, O. Kranenburg, D. Matic Vignjevic, M. Gloerich

This study shows that mechanical signals from the Collagen I-rich matrix drive fate transitions in colorectal cancer cells, enabling metastasis despite lacking Lgr5 expression.

bioRxiv · Sep 17, 2023 · PreprintCancer Biology

Low centrosome numbers correlate with higher aggressivity in ovarian cancer

J.-P. Morretton, A. Simon, A. Herbette, J. Barbazan, C. Perez-Gonzalez, C. Cosson, B. Mboup, A. Latouche, T. Popova, Y. Kieffer, P. Gestraud, G. Bataillon, V. Becette, D. Meseure, A. Nicolas, , R. Basto

The paper analyzes centrosome numbers in ovarian cancers and finds that low centrosome numbers correlate with poor patient survival and mesenchymal subgroup enrichment.

bioRxiv · Jan 4, 2022 · PreprintCancer Biology

Cancer-associated fibroblasts actively compress cancer cells and modulate mechanotransduction

J. Barbazan, C. Perez-Gonzalez, M. Gomez-Gonzalez, M. Dedenon, S. Richon, E. Latorre, M. Serra, P. Mariani, S. Descroix, P. Sens, X. Trepat, D. Matic-Vignjevic

This study shows cancer-associated fibroblasts actively compress cancer cells via actomyosin contractility, altering YAP localization and tumor morphology.

bioRxiv · Apr 5, 2021Cell Biology

Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration

C. Perez-Gonzalez, G. Ceada, F. Greco, M. Matejcic, M. Gomez-Gonzalez, N. Castro, S. Kale, A. Alvarez-Varela, P. Roca-Cusachs, E. Batlle, D. M. Vignjevic, M. Arroyo, X. Trepat

This study maps mechanical forces in mouse intestinal organoids, revealing how stress patterns drive crypt folding and cell migration through compartmentalization.

bioRxiv · Sep 20, 2020Cell Biology

Iron limitation by transferrin promotes simultaneous cheating of pyoverdine and exoprotease in Pseudomonas aeruginosa

O. Tostado-Islas, A. Mendoza-Ortiz, G. Ramirez-Garcia, I. D. Cabrera-Takane, D. Loarca, C. Perez-Gonzalez, R. Jasso-Chavez, J. G. Jimenez-Cortes, Y. Hoshiko, T. Maeda, A. Cazares, R. Garcia-Contreras

The paper shows that using transferrin as an iron chelator selects for mutants lacking both pyoverdine and exoprotease production in Pseudomonas aeruginosa.

bioRxiv · Jun 21, 2020Microbiology

Unveiling the multi-step solubilization mechanism of single vesicles by detergents.

P. A. Dalgarno, J. Juan-Colas, G. J. Hedley, L. Pineiro, M. Novo, C. Perez-Gonzalez, I. D. W. Samuel, M. C. Leake, S. Johnson, W. Al-Soufi, J. C. Penedo, S. D. Quinn

This study uses svFRET to reveal the biphasic solubilization kinetics of vesicles by detergents, identifying an initial fast swelling step followed by slow lipid loss and micellization.

bioRxiv · May 15, 2019Biophysics

Intermediate filaments control collective migration by restricting traction forces and sustaining cell-cell contacts

C. De Pascalis, C. Perez-Gonzalez, S. Seetharaman, B. Boeda, B. Vianay, M. Burute, C. Leduc, N. Borghi, X. Trepat, S. Etienne-Manneville

bioRxiv · May 23, 2018Cell Biology

A Notch-regulated proliferative stem cell zone in the developing spinal cord is an ancestral vertebrate trait

R. Lara-Ramirez, C. Perez-Gonzalez, C. Anselmi, C. Patthey, S. M. Shimeld

The paper identifies a Notch-regulated proliferative stem cell zone in lamprey spinal cord, linking it to vertebrate nervous system complexity.

bioRxiv · Apr 11, 2018Evolutionary Biology