Author

J. C. Penedo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:microscopy & imaging analysis· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

R. T. Hay· 2 shared C. Perez-Gonzalez· 1 shared E. Branigan· 1 shared G. J. Hedley· 1 shared I. D. W. Samuel· 1 shared J. Juan-Colas· 1 shared L. Pineiro· 1 shared M. C. Leake· 1 shared

Activity by Year

2019-2019 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

R. T. Hay

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Author profile →

3 papers

Recent·Most cited

Ubiquitin transfer by a RING E3 ligase occurs from a closed E2~Ub conformation

E. Branigan, J. C. Penedo, R. T. Hay

This study uses smFRET to show that ubiquitin transfer by RING E3 ligases occurs from a closed E2~Ub conformation.

bioRxiv · Nov 20, 2019Biochemistry

Functional 3D architecture in an intrinsically disordered E3 ligase domain facilitates ubiquitin transfer

P. Murphy, Y. Xu, S. L. Rouse, S. J. Matthews, J. C. Penedo, R. T. Hay

This study reveals how the intrinsically disordered substrate-recognition domain of RNF4 adopts a defined 3D architecture to facilitate SUMO binding and ubiquitin transfer.

bioRxiv · Nov 5, 2019Biophysics

Unveiling the multi-step solubilization mechanism of single vesicles by detergents.

P. A. Dalgarno, J. Juan-Colas, G. J. Hedley, L. Pineiro, M. Novo, C. Perez-Gonzalez, I. D. W. Samuel, M. C. Leake, S. Johnson, W. Al-Soufi, J. C. Penedo, S. D. Quinn

This study uses svFRET to reveal the biphasic solubilization kinetics of vesicles by detergents, identifying an initial fast swelling step followed by slow lipid loss and micellization.

bioRxiv · May 15, 2019Biophysics