Author

S. D. Quinn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:fluorescence / live-cell microscopy· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:microscopy & imaging analysis· 2 Approach:biophysical modeling· 1 Research Focus:clustering· 1 Organism:human· 1

Frequent Co-Authors

M. C. Leake· 7 shared S. Johnson· 4 shared D. Conteduca· 3 shared L. Dresser· 3 shared J. Juan-Colas· 2 shared L. G. Dresser· 2 shared A. Burns· 1 shared B. Zhang· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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7 shared papersBiophysics

M. C. Leake

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Author profile →

8 papers

Recent·Most cited

Multiple Intermediates in the Detergent-Induced Fusion of Lipid Vesicles

L. G. Dresser, C. Kunstmann-Olsen, D. Conteduca, C. M. Hofmair, N. Smith, L. Clark, S. Johnson, C. Penedo, M. C. Leake, S. D. Quinn

This study identifies multiple intermediates in detergent-induced vesicle fusion using FRET and single-vesicle analysis, revealing a multi-step mechanism involving permeabilization, docking, hemi-fusion, and lipid mixing.

bioRxiv · Sep 21, 2023Biophysics

Correlating viscosity and molecular crowding with fluorescent nanobeads and molecular probes: in vitro and in vivo

S. Lecinski, J. W. Shepherd, K. Bunting, L. Dresser, S. D. Quinn, C. MacDonald, M. C. Leake

The paper investigates intracellular viscosity and molecular crowding using fluorescent nanobeads and molecular probes in vitro and in live yeast cells.

bioRxiv · Jun 27, 2022Biophysics

Crowding induced morphological changes in synthetic lipid vesicles determined using smFRET

S. D. Quinn, L. Dresser, S. Graham, D. Conteduca, J. Shepherd, M. C. Leake

This study investigates how molecular crowding affects synthetic lipid vesicle morphology using smFRET and other techniques, finding that crowding induces compaction with varying reversibility depending on the crowder type.

bioRxiv · May 31, 2022Biophysics

Tween-20 induces the structural remodelling of single lipid vesicles

L. G. Dresser, S. P. Graham, L. M. Miller, C. Schaefer, D. Conteduca, S. Johnson, M. C. Leake, S. D. Quinn

This study investigates how Tween-20 interacts with lipid vesicles, revealing stepwise structural changes even below critical micellar concentration.

bioRxiv · Mar 1, 2022 · PreprintBiophysics

Ligand-induced transmembrane conformational coupling in monomeric EGFR

S. Srinivasan, R. Regmi, X. Lin, C. A. Dreyer, X. Chen, S. D. Quinn, W. He, K. L. Carraway, M. A. Coleman, B. Zhang, G. S. Schlau-Cohen

This study shows ligand binding causes intracellular conformational changes in monomeric EGFR, linking extracellular and intracellular regions through the transmembrane helix.

bioRxiv · Oct 28, 2021Biophysics

The Mechanism of Vesicle Solubilization by the Detergent Sodium Dodecyl Sulfate

J. Juan-Colas, L. Dresser, K. Morris, H. Lagadou, R. H. Ward, A. Burns, S. Tear, S. Johnson, M. C. Leake, S. D. Quinn

This study investigates the molecular dynamics of vesicle solubilization by SDS using advanced biophysical methods, revealing biphasic kinetics involving vesicle expansion and rapid lipid loss.

Langmuir · Oct 6, 2020Peer-reviewedBiophysics

Single-molecule FRET dynamics of molecular motors in an ABEL Trap

M. Dienerowitz, J. A. L. Howard, S. D. Quinn, F. Dienerowitz, M. C. Leake

This paper demonstrates the use of ABEL traps for extended smFRET measurements of the molecular motor Rep, capturing conformational changes with sub-millisecond resolution.

bioRxiv · Sep 21, 2020Biophysics

Unveiling the multi-step solubilization mechanism of single vesicles by detergents.

P. A. Dalgarno, J. Juan-Colas, G. J. Hedley, L. Pineiro, M. Novo, C. Perez-Gonzalez, I. D. W. Samuel, M. C. Leake, S. Johnson, W. Al-Soufi, J. C. Penedo, S. D. Quinn

This study uses svFRET to reveal the biphasic solubilization kinetics of vesicles by detergents, identifying an initial fast swelling step followed by slow lipid loss and micellization.

bioRxiv · May 15, 2019Biophysics