L. Poirot

Stromal depletion by TALEN-edited universal hypoimmunogenic FAP-CAR T cells enables infiltration and anti-tumor cytotoxicity of tumor antigen-targeted CAR-T immunotherapy.

This study develops FAP-targeted CAR-T cells to deplete stromal CAFs, enhancing tumor infiltration and anti-tumor activity in solid tumors.

Endowing Universal CAR T-cell with Immune-Evasive Properties using TALEN-Gene Editing.

This paper develops a novel CAR T-cell scaffold with immune-evasive properties to enable universal allogeneic CAR T-cell therapy.