Host cell cAMP-Epac pathway inhibition by hawthorn extract as a potential treatment for Chagas disease
G. Ferri, L. R. Fernandez, G. T. Di Mario, J. A. Palermo, M. M. Edreira
This paper investigates hawthorn extract's effect on the host cell cAMP-Epac pathway, showing it inhibits Trypanosoma cruzi invasion and synergizes with nifurtimox to reduce treatment toxicity and cost.
bioRxiv · Jan 26, 2023 · PreprintMicrobiology