L. Rems

Identification of electroporation sites in the complex lipid organization of the plasma membrane

This study identifies electroporation sites in the plasma membrane by combining simulations, machine learning, and Bayesian analysis, showing pores form in lipid domains with high polyunsaturated lipid density and depend on mechanical properties and electric field polarity.

Pulsed electric fields create pores in the voltage sensors of voltage-gated ion channels

This study uses molecular dynamics simulations to show that pulsed electric fields create pores in voltage-sensor domains of voltage-gated ion channels, leading to dysfunction and altered ionic currents.

Unraveling the response of a biomimetic actin cortex to electric pulses in vesicles

This study examines how an actin cortex in giant unilamellar vesicles affects electroporation and membrane resealing in response to electric pulses.