GBP2 aggregates LPS and activates the caspase-4 inflammasome independent of the bacterial encapsulation factor GBP1
M. S. Dickinson, M. Kutsch, L. Sistemich, D. Hernandez, D. Needham, c. lesser, C. Herrmann, J. Coers
This paper shows GBP2 can trigger pyroptosis by aggregating free LPS and activating caspase-4, independent of GBP1's bacterial binding function.
Proceedings of the National Academy of Sciences · Apr 6, 2023Peer-reviewedImmunology