The structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin
M. I. Flydal, M. Alcorlo-Pages, F. G. Johannessen, S. Martinez-Caballero, L. Skaejrven, R. Fernandez-Leiro, A. Martinez, J. A. Hermoso
This paper presents the first crystal and cryo-EM structures of full-length human PAH with and without BH4, revealing structural dynamics and allosteric mechanisms related to PKU.
bioRxiv · Feb 22, 2019Biochemistry